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Krzysztof Lewandowski 1,, Agata Cajdler-Luba 2, Malgorzata Bienkiewicz 3 & Andrzej Lewinski 1, In support of the 'Rotterdam' PCOS criteria: Identical LH responses to GnRH stimulation in women with oligo-/amenorrhoea and polycystic ovaries regardless of androgen status

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@inproceedings{CajdlerLuba2010GnRHTA, title={GnRH test as an additional investigation in the diagnosis of polycystic ovary syndrome (PCOS): potential application of stimulated LH/FSH ratio}, author={Agata Cajdler-Luba and Krzysztof C. Lewandowski and Małgorzata Bieńkiewicz and Ireneusz Sałata and Andrzej Lewiński}, year={2010} }

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Articles by author - Agata Cajdler-Luba.. Lewandowski K, Cajdler-Luba A, Bieńkiewicz M, Lewiński A. Women with oligo-/amenorrhoea and polycystic ovaries have identical responses to GnRH stimulation regardless of their androgen status: comparison of the Rotterdam and Androgen Excess Society diagnostic criteria..

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Fig. 2B. Mean values of LH/FSH ratio during GnRH test in women with PCOS and androgens within the reference range (PCOS-NA) and at least a single androgen concentration higher than the - "Women with oligo-/amenorrhoea and polycystic ovaries have identical responses to GnRH stimulation regardless of their androgen status: comparison of the Rotterdam and Androgen Excess Society diagnostic criteria."

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Introduction: Polycystic ovary syndrome (PCOS) is characterised by increased frequency of hypothalamic GnRH pulses leading to a relative increase in LH synthesis by the pituitary. As GnRH stimulation can reveal a relative LH excess, we have endeavoured to assess whether GnRH test might be useful in the diagnosis of PCOS.

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Objective: As increased frequency of gonadotrophin-releasing hormone (GnRH) pulses is characteristic for polycystic ovary syndrome (PCOS), we assessed gonadotrophin response to GnRH in women with PCOS with normal and raised androgens and in regularly menstruating controls. Design, patients and methods: The study involved 155 subjects: PCOS, n=121, age (mean±SD) 24.8±5.4 yrs, BMI 24.5±6.0 kg.

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It is suggested that an abnormality in the regulation of hypothalamic GnRH secretion is present in PCOS and may be a factor in the etiology of the disorder in adolescence. Plasma LH is commonly elevated in women with the polycystic ovary syndrome (PCOS), but the underlying mechanisms are uncertain. We tested the hypothesis that the elevated LH in part reflects a reduced sensitivity of the.

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Fig. 2A. Mean LH concentrations [IU/l] during GnRH test in women with PCOS and normal androgens (PCOS-NA) and notnormal androgens (PCOS-NNA) and in regularly menstruating controls. Vertical bars represent 95% confidence intervals in - "Women with oligo-/amenorrhoea and polycystic ovaries have identical responses to GnRH stimulation regardless of their androgen status: comparison of the.

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Agata Cajdler-Luba 1 , Krzysztof Lewandowski 1 , Malgorzata Bienkiewicz 2 , Ireneusz Salata 1 & Andrzej Lewinski 1 Author affiliations Diagnosis of PCOS may be sometimes difficult, e.g. due to limited sensitivity of androgen assays and discrepancies in interpretation of ovarian ultrasound imaging.

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Agata Cajdler-Luba Małgorzata Bieńkiewicz Andrzej Lewiński As increased frequency of gonadotrophin-releasing hormone (GnRH) pulses is characteristic for polycystic ovary syndrome (PCOS), we.